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CELLINK BIO X 生物3D打印系统

发布时间:2020-03-23 浏览次数:1183

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CELLINK生物3D打印机可以在空间定向操纵多种活细胞构建仿生三维组织,这样不仅可以制造特定形状的结构,还可以搭配合适的生物墨水(具有良好生物兼容性的多聚物,如胶原、明胶、透明质酸等)提供细胞三维培养的环境,目前主要应用于打印软骨、皮肤、血管、以及用于药物筛选和机理机制研究的肿瘤模型等。


CELLINK公司简介

CELLINK创立于2016年,是世界首家生物墨水制造商。公司成立仅10个月就在纳斯达克上市。在为用户提供高水平生物墨水的同时,CELLINK基于用户反馈开发了一系列生物打印机,短短四年时间已成为生物3D打印领域的佼佼者。用户遍及50多个国家的700余实验室,既有哈佛大学、斯坦福大学、剑桥大学等知名学术机构,也不乏罗氏、诺华、默克等知名企业。

BIO 采用挤压式打印方式,是适用于生物科研机构、创新型科研工作者的新一代生物3D打印机,BIO X的响应性新皮层M1内置计算机允许使用者调控复杂的人体组织打印流程,是目前最易于使用且是功能性学科一直期待的生物3D打印设备。

配有高效微粒捕捉空气过滤系统;

三个可替换的打印头、适合300多种打印生物材料;

可调节温度的打印床;

触控式设计,可带手套操作;


CELLINK BIO X 生物3D打印系统优势

压缩型:小身材大智慧,包含工作所需全部原件

便捷性:智能及可更换的打印头,三重喷出结构,可以对更为复杂的组织模型实现生物打印

多打印头:热熔挤出式,温控打印头,电磁液滴打印头,注射器打印头,高清摄像头工具头,光固化工具头等

高性能:心脏、皮肤、软骨或骨头等都可打印

高兼容性:多种不同的打印头,适合300多种打印生物材料

固化系统:365nm&405nm紫外线光固化系统,可更换的UV-LED

高精度打印:最小打印精度:5纳升;XYZ轴定位精度:2微米



应用文献

Microextrusion Printing Cell-Laden Networks of Type I Collagen with Patterned Anisotropy and Geomtery. (2019).Acta Biomaterialia

Tissue-mimicking gelatin scaffolds by alginate sacrificial templates for adipose tissue engineering. (2019).Acta Biomaterialia

Mouse in vitro spermatogenesis on alginate-based 3D bioprinted scaffolds. (2019).Biofabrication

Extrusion-based printing of sacrificial Carbopol ink for fabrication of microfluidic evices (2019).Biofabrication

Process- and bio-inspired hydrogels for 3D bioprinting of soft free-standing neural and glial tissues. (2019). Biofabrication

Formulation and Characterization of a SIS-Based Photocrosslinkable Bioink. (2019).Polymers

Multi-channel silk sponge mimicking bone marrow vascular niche forplatelet production.(2018).Biomaterials

Mechanical behaviour of alginate-gelatin hydrogels for 3D bioprinting.  (2018).   Journal of the mechanical behavior of

biomedical materials

3D Bioprinting and Stem Cells .(2018). Somatic Stem cells

3D printing of PDMS improves its   mechanical and cell adhesion properties Skin Grafting on 3D Bioprinted Cartilage Constructs In Vivo. (2018). ACS Biomaterials Science & Engineering

Bioprinted (3D) co-cultured spheroids with NSCLC PDX cells and cancer associated fibroblasts (CAFs) using alginate/gelatin hydrogel.(2018) .AACR, Cancer research
Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus.(2018).Scientific reports
Fabrication of naftopidil-loaded tablets using a semi-solid extrusion-type 3D printer, and the characteristics of the printed hydrogel and resulting tablets. (2018). Journal of pharmaceutical sciences
High-resolution patterned cellular constructs by droplet-based 3D printing. (2017). Scientific reports
Combination of CDODA-Me, a glycyrrhetinic acid derivative, and Erlotinib overcomes chemo-resistance in NSCLC PDX spheroids and 3D bio-printed cells. 
(2017).AACR, Cancer Research.
Controlling adult stem cell behavior using nanodiamond-reinforced hydrogel: Implication in bone regeneration therapy. (2017).Scientific Reports
Increased lipid accumulation and adipogenic gene expression of adipocytes in 3D bioprinted nanocellulose scaffolds. (2017). Biofabrication


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